Analgesic Effect of the Chloroformic Extract of Aniba canelilla “canelon” Bark in BALB/c Mice

Abstract

Background. Some diseases can cause intense pain, where pharmacological treatment with opioid analgesics is necessary, as in cancer. Despite advances in cancer treatment, pain is still a common symptom. Treatment is usually based on the use of opioids, but there is still some rejection because of their adverse effects or because of the delay in access to them. To evaluate the analgesic effect of Aniba canelilla "canelon" bark in mice to validate the above and consider it an alternative to existing palliative treatment in cancer patients. Methodology. The analgesic effect was evaluated according to the method of Koster et al. using 50 BALB/c mice distributed in groups of 07 mice each. Comparison was made with the standards Tramadol 50 mg/kg and Paracetamol 500 mg/kg administered orally, and acetic acid 0.8% was used intraperitoneally as a pain inducer. Results. The potent analgesic effect of the chloroformic extract of Aniba canelilla at 200mg/kg was observed, with an analgesic percentage of 98.87% with a mean number of writhes of 28.29 ± 5.44, being statistically significant to the other treatments (p<0.01). Conclusions The analgesic effect of the chloroformic extract of Aniba canelilla at 200mg/kg was determined. © 2025 Elsevier B.V., All rights reserved.